Research, Development and Licensing
Technology for active, bioactive and intelligent medical devices

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History

Year

Event

September 2014

Collaboration project between Morphoplant, BirdC and TU Wien has been successfully finished. A GMP-compliant production preocess for BMP-2 has been established

August 2014

Successfull recombinant production of stem cell homing factor SDF-1

May 2014

Bioactive BMP-2 and VEGF have been incorporated into electro-spun PDLLA nano-composites fleeces. These fleeces might mimic the native extracellular matrix of bone tissue, stimulating angiogenesis and osteogenesis

January 2013

Development of an fully automated etching- and dry packaging robot in collaboration with an equipment manufacturer

August 2012

First preclinical in vivo-studies on VEGF and VEGF/ BMP-2 coated bone replacement implants

June 2012

Development of a biocompatible bone glue

October 2011

Morphoplant in collaboration with Bird-C/ Vienna and Technical University Vienna receives grand for the development of a GMP-compliant production process for BMP-2/ VEGF using Bird-C's proprietary bacterial ghost technology

September 2011

BMBF funding of "BioMin" project - Functionalized mineral surface by immobilization of growth stimulating proteins

March 2010

First preclinical in vivo-studies reveal strong stimulation of bone and osteoid ongrowth for ultrahydrophilic and rhBMP-2 coated titan-plasma-sprayed surfaces

May 2009

Morphoplant moves to larger laboratory space at the BioMedizinZentrum Ruhr in Bochum/ Germany

February 2009

First preclinical in vivo-studies in cooperation with SpineWelding AG, Schlieren/ Switzerland proofing rhBMP-2-coated PDLLA/ Algisorb-membranes suitable as drug delivery devices

December 2008

First clinical pilot study using rhBMP-2 coated bone replacement materials

January 2007

First preclinical in vivo-studies demonstrate strongly enhanced bone growth for rhBMP-2 coated phycogenic bone replacement materials using Morphoplants coating technology as well as for foamed rhBMP2/Poly-(D,L)-Lactide moulds

August 2006

First systematic preclinical in vivo-studies corroborating superior effects of Morphoplants ultrahydrophilic and rhBMP-2 coated dental implant SLA-surfaces

Februar 2006

AiF funding of "Boneadapt" project - Production of BMP-2 loaded osteoinductive ceramic bone replacement materials

October 2004

Preclinical in vivo-studies prooving high biological activity of Morphoplants rhBMP-2

June 2004

Morphoplant receives funding within "NRW/ EU Ziel 2-Programm 2000-2006"

May 2003

Moving into research laboratories located at Ruhr-University Bochum

December 2002

Morphoplant was founded as a spin-off of the University Duisburg-Essen