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In Vivo Bioactivity

  • critical size defect model (ribs/ sheep)
  • empty defect (control) vs. uncoated vs. BMP-2 coated BRM


  • control: no bone formation
  • BRM – BMP-2: marginal bone formation, no resorption of BRM
  • BRM + BMP-2: extensive bone formation, strongly corresponding resorption of BRM